ENI seminar An experience dependent comparator circuit in layer 2/3 of mouse visual cortex |  |  |
Speaker:Dr. Georg Keller, Friedrich Miescher Institute, Basel
Location:European Neuroscience Institute Göttingen (ENI-G), Grisebachstraße 5Seminar roomGras Geo Map
Organizer:European Neuroscience Institute
Details:
I will argue that the computational function of layer 2/3 of primary visual cortex of the mouse is that of a comparison between predicted and actual visual input. There is a dense, retinotopic projection from anterior cingulate cortex to layer 2/3 of primary visual cortex that conveys a prediction of visual flow based on motor output. This excitatory prediction of visual input is compared to feed forward visual input in layer 2/3 by a canonical inhibitory circuit that involves SST and VIP interneurons. The output of the comparison is a mismatch that signals a deviation from expectation. The comparison of the excitatory top-down and inhibitory feed-forward input is finely tuned during sensorimotor experience in an NMDA receptor dependent fashion. Based on this, we postulate that the function of the cortical visual system may be the generation of an internal model of the visual environment that is continuously compared to and updated by visual input.
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Type:Talk
Language:English
Category:Research
Host:Dr. Caspar Schwiedrzik
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Direct link to event:https://events.goettingen-campus.de/event?eventId=14033
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