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PRODID:-//Event Calendar 2.0//iCal4j 2.0//EN
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VERSION:2.0
BEGIN:VEVENT
DTSTAMP:20261010T053728Z
DTSTART:20260917T160000
DTEND:20260917T170000
SUMMARY:Toshiya Endo: Pathways and machineries for mitochondrial biogenesis and maintenance
TZID:Europe/Berlin
UID:event-1787323434590@events.goettingen-campus.de
LOCATION:Anderer Ort / Other Location - Lecture Hall 0.101 - Humboldtallee 23
CONTACT:Susann Meyer\, susann.meyer@med.uni-goettingen.de\, 0551 3961944
CATEGORIES:research
DESCRIPTION:Mitochondria are central to energy production\, metabolism\, signaling\, and cellular homeostasis in eukaryotic cells. Because mitochondria cannot be generated de novo\,\nthey are propagated through growth and division of pre-existing mitochondria. Since most mitochondrial proteins and lipids are supplied from outside mitochondria\,\nmitochondrial expansion requires the continuous supply of newly synthesized proteins and lipids\, mediated by protein translocators and the lipid transfer systems\, respectively.\nIn contrast\, a limited set of proteins is encoded by the mitochondrial genome and synthesized within mitochondria\, while certain lipids\, including cardiolipin and\nphosphatidylethanolamine\, are synthesized within mitochondria for imported precursors.\nThus\, the coordinated assembly of mitochondrial proteins and lipids produced both within and outside mitochondria is essential for mitochondrial biogenesis and proliferation.\nTo maintain mitochondrial function\, mitochondrial proteins are constantly monitored for their quality\, and dysfunctional or mislocalized mitochondrial proteins are properly recognized and eliminated or rerouted. These quality control systems include recently identified protein extractases operating in mitochondria\, the ER\, and peroxisomes\, which contribute to maintaining proper protein distribution among organelles. Recent studies have also revealed roles for mitochondrial RNA import and the escape of mitochondrial DNA from mitochondria in mitochondrial proteostasis and cellular homeostasis.\nIn this seminar\, I will present and discuss recent findings from our lab on these topics\, with a particular focus on how the trafficking of proteins lipids\, and nucleic acid\ncontributes to mitochondrial biogenesis\, quality control\, and cellular homeostasis.\n\nTitle: MBExC Lecture: Pathways and machineries for mitochondrial biogenesis and maintenance\nSpeaker: Toshiya Endo\nOrganizer: Exzellenzcluster Multiscale Bioimaging (MBExC)\, Zentralverwaltung und sonstige zentralen Einrichtungen\nHost: Peter Rehling\nContact: Susann Meyer\, susann.meyer@med.uni-goettingen.de\, 0551 3961944\n
URL:https://events.goettingen-campus.de/event?eventId=1787323434590
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