ENI zoominar Investigating the roles of TLDc proteins in neurodevelopment, neurodegeneration and neuroprotection |  |  |
Vortragende Person:Peter Oliver, Medical Science Division, University of Oxford
Veranstaltungsort:Anderer Ort/Other Locationhttps://uni-goettingen.zoom.us/webinar/register/WN_GhCsKiXGRVqZcUmyrSdj8A
Veranstalter:European Neuroscience Institute
Beschreibung:
Members of the TLDc protein family are associated with a range of neurological disorders characterised by epilepsy,
neurodegeneration and neurodevelopmental delay. The TLDc domain itself is highly conserved across species,
although the structure-function relationship is unknown. To understand the role of this domain in the stress
response and disease, we are carrying out systematic functional analysis of TLDc domain-containing proteins as well as investigating their neuroprotective properties in mouse models of neurodegeneration. We also revealed for the
first time the essential role of the epilepsy-associated TLDc family member TBC1D24 at the mammalian synapse and are now focussing on a new function for TLDc proteins in vesicular trafficking, combining electrophysiology and
three-dimensional structural studies of the synapse with cell biology and biochemical approaches.
neurodegeneration and neurodevelopmental delay. The TLDc domain itself is highly conserved across species,
although the structure-function relationship is unknown. To understand the role of this domain in the stress
response and disease, we are carrying out systematic functional analysis of TLDc domain-containing proteins as well as investigating their neuroprotective properties in mouse models of neurodegeneration. We also revealed for the
first time the essential role of the epilepsy-associated TLDc family member TBC1D24 at the mammalian synapse and are now focussing on a new function for TLDc proteins in vesicular trafficking, combining electrophysiology and
three-dimensional structural studies of the synapse with cell biology and biochemical approaches.
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Veranstaltungsart:Vortrag
Veranstaltungssprache:Englisch
Kategorie:Forschung
Name der einladenden Person:Dr. Ira Milosevic
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Direkter Link zur Veranstaltung:https://events.goettingen-campus.de/event?eventId=23565
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